# Neuropsychiatric symptoms in Fabry disease: a review of psychiatric clinical features, neuroimaging, and treatment - URL: https://alisanburak.com/en/wcp-2026-posterler/so027 - Language: en - Last updated: not specified - Page title: Neuropsychiatric symptoms in Fabry disease: a review of psychiatric clinical features, neuroimaging, and treatment | WCP 2026 Summary > Depression, anxiety, and cognitive impairment are common comorbidities in Fabry disease but remain underrecognized due to diagnostic delays, while psychotic sy… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/so027) Bu sayfa, 26. Dünya Psikiyatri Kongresi'nde sunulan çalışmanın yapay zekâ desteğiyle hazırlanmış Türkçe özetidir. Çalışmanın sahibi sunan yazarlardır; atıf için orijinal kaynağa başvurun. SO027 Kısa Sözlü Poster SunumuKonsültasyon-LiyezonDerleme # Neuropsychiatric symptoms in Fabry disease: a review of psychiatric clinical features, neuroimaging, and treatment NEUROPSYCHIATRIC MANIFESTATIONS IN FABRY DISEASE: A REVIEW OF PSYCHIATRIC CLINICAL FEATURES, NEUROIMAGING, AND MANAGEMENT Sunan: Mohammad Aboutalebi Ülke: Germany Kurum: Karl Jaspers Clinic, Dept. of Psychiatry and Psychotherapy, University of Oldenburg Oturum: 2620 - PARALLEL SHORT ORAL POSTER SESSIONS: PSYCHOSIS & SCHIZOPHRENIA - Part I Tarih: Thu, 24.09.2026 Depression, anxiety, and cognitive impairment are common comorbidities in Fabry disease but remain underrecognized due to diagnostic delays, while psychotic symptoms are rare and predominantly secondary. This study aims to clarify the undercharacterized neuropsychiatric profile of Fabry disease (FD), particularly the nature of psychotic symptoms. FD is an X-linked lysosomal storage disorder caused by GLA gene mutations and characterized by alpha-galactosidase A deficiency and globotriaosylceramide accumulation. Eight primary studies published between 2000 and 2025 were reviewed, evaluating the prevalence, clinical features, and pathophysiology of depression, chronic pain, and psychosis, as well as diagnostic approaches, neuroimaging findings, and treatment strategies, including enzyme replacement therapy (ERT). The poster highlights that depression has been reported in up to 60% of patients, that the typical diagnostic delay is 5 to 15 years, and that psychotic symptoms are rare. The pathophysiology of psychiatric symptoms is described as multifactorial, with a chain extending from GLA mutations to cerebrovascular/ischemic changes, then to chronic pain and psychosocial stress, and ultimately to neuropsychiatric symptoms. Neuroimaging findings suggest that structural brain changes may be associated with neuropathic pain and major depression, and that white matter lesions may contribute to cognitive symptoms. The clinical features section notes that depression is associated with pain, fatigue, and social withdrawal; that mood and anxiety disorders are common comorbidities; and that psychotic symptoms reflect secondary psychosis due to vascular or neurodegenerative changes rather than primary psychotic disorders. The authors emphasize that early screening and routine psychiatric assessment are essential, and that a multidisciplinary approach combining ERT, specialized pharmacotherapy, psychotherapy, and pain management is necessary to reduce disease burden and improve long-term quality of life. [Orijinal postere git](https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/2026) Bu çalışmaya nasıl atıf yapılır? APA 7: Aboutalebi, M., et al. (2026, September 24). Neuropsychiatric manifestations in fabry disease: a review of psychiatric clinical features, neuroimaging, and management [Poster presentation]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/2026 Vancouver: Aboutalebi M, et al. Neuropsychiatric manifestations in fabry disease: a review of psychiatric clinical features, neuroimaging, and management [poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Available from: https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/2026 Yazar adları ve başlık biçimi kongre sisteminden otomatik oluşturulmuştur; kullanmadan önce orijinal posterle karşılaştırın. ## Aynı konudan - [Nöroonkolojide bakıma engel olarak barınma güvencesizliği: bir olgu serisi ve literatür derlemesi](https://alisanburak.com/en/wcp-2026-posterler/ev0092) - [Bipolar bozukluğun manik epizoduyla ilişkili kutanöz liken planus alevlenmesi: olgu sunumu](https://alisanburak.com/en/wcp-2026-posterler/ev0208) - [Ayrı bir psikiyatrik durum olarak zihin bulanıklığı: anlatısal derleme ve tanısal sınıflandırma için kavramsal çerçeve](https://alisanburak.com/en/wcp-2026-posterler/ev0294) - [Hipertiroidide geri dönüşlü psikoz ve mani: olgu sunumları ve olgu serilerinin sistematik derlemesi](https://alisanburak.com/en/wcp-2026-posterler/ev0340) - [Kronik somatik hastalıklarda (diabetes mellitus, arteriyel hipertansiyon ve kronik solunum hastalıkları) eşlik eden depresyon](https://alisanburak.com/en/wcp-2026-posterler/ev0344) [Tüm WCP 2026 özetleri](https://alisanburak.com/en/wcp-2026-posterler) --- Kaynak / Source: https://alisanburak.com/en/wcp-2026-posterler/so027 İletişim / Contact: Bağdat Caddesi, Veli Güneysu Apt. 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