# Safety and tolerability of second-generation antipsychotics in a pediatric cohort: a real-world longitudinal study - URL: https://alisanburak.com/en/wcp-2026-posterler/so003 - Language: en - Last updated: not specified - Page title: Safety and tolerability of second-generation antipsychotics in a pediatric cohort: a real-world longitudinal study | WCP 2026 Summary > Over six months of follow-up, cardiovascular, hepatic, and lipid profiles remained stable with second-generation antipsychotics, but substantial increases in w… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/so003) Bu sayfa, 26. Dünya Psikiyatri Kongresi'nde sunulan çalışmanın yapay zekâ desteğiyle hazırlanmış Türkçe özetidir. Çalışmanın sahibi sunan yazarlardır; atıf için orijinal kaynağa başvurun. SO003 Kısa Sözlü Poster SunumuPsikofarmakolojiProspektif gözlemsel kohort # Safety and tolerability of second-generation antipsychotics in a pediatric cohort: a real-world longitudinal study SAFETY AND TOLERABILITY OF SECOND-GENERATION ANTIPSYCHOTICS IN A PEDIATRIC COHORT: A REAL LIFE LONGITUDINAL STUDY Sunan: Grazia Maria Giovanna Pastorino Ülke: Italy Kurum: Magna Graecia University of Catanzaro, Department of Health Sciences Oturum: 2580 - PARALLEL SHORT ORAL POSTER SESSIONS: CHILD & DEVELOPMENTAL PSYCHIATRY - Part I Tarih: Thu, 24.09.2026 Over six months of follow-up, cardiovascular, hepatic, and lipid profiles remained stable with second-generation antipsychotics, but substantial increases in weight, waist circumference, and prolactin were observed, particularly with risperidone. The study aimed to evaluate the six-month cardiometabolic, endocrine, and cardiovascular safety of second-generation antipsychotics (SGAs) in children and adolescents under naturalistic follow-up conditions. This prospective observational study enrolled 68 patients aged 6–17 years (13.5±2.7 years; 64.7% male; mean number of comorbidities per patient: 1.59±0.98). Anthropometric measures, blood pressure, resting heart rate, QTc (Bazett) on a 12-lead ECG, and laboratory parameters were assessed at baseline (T0), month 3 (T1), and month 6 (T2). Longitudinal trajectories and between-drug differences (Time x Drug interaction) were examined using linear mixed-effects models (LMMs) adjusted for age, biological sex, and socioeconomic status. Primary diagnoses comprised conduct disorder (n=18, 26.5%), ADHD (n=14, 20.6%), obsessive-compulsive disorder (n=11, 16.2%), autism spectrum disorder (n=10, 14.7%), bipolar disorder (n=9, 13.2%), and other diagnoses (n=6, 8.8%). Treatments were risperidone (n=30, 44.1%), aripiprazole (n=20, 29.4%), quetiapine (n=7, 10.3%), combined risperidone and aripiprazole (n=7, 10.3%), and lurasidone (n=4, 5.9%), with a six-month treatment retention rate of 91.2% (62/68). Across the full sample, body weight (β=+4.87 kg, p<0.001) and waist circumference (β=+2.90 cm, p<0.001) increased significantly; blood pressure and heart rate remained stable (p>0.17), while QTc increased slightly (+6.0 ms, p=0.018), with no patient reaching a QTc of 430 ms. Transaminases and lipid profiles remained generally stable (p>0.05), while slight increases in gamma-GT and prolactin were detected (p<0.05). Risperidone was associated with greater increases in weight (β=+2.72 kg, p=0.037) and waist circumference (β=+5.64 cm, p<0.001) than aripiprazole. Prolactin increased with risperidone but remained stable with aripiprazole (Time x Drug interaction p<0.001), and slight increases in ALT and total cholesterol were observed only in the risperidone group (p<0.05). At baseline, patients receiving risperidone were younger (12.1 versus 14.0 years, p=0.007), while other baseline measures were similar between groups (p>0.05). Adverse events were mild and transient in 5 patients, and 2 patients discontinued treatment because of aripiprazole-related akathisia/activation. The authors conclude that the safety profile was maintained over the medium term, but that increases in weight and central adiposity, particularly with risperidone, warrant percentile-based metabolic monitoring from the start of treatment. They note that the small sample size and naturalistic follow-up design limit causal inference. [Orijinal postere git](https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1539) Bu çalışmaya nasıl atıf yapılır? APA 7: Pastorino, G. M. G., et al. (2026, September 24). Safety and tolerability of second-generation antipsychotics in a pediatric cohort: a real life longitudinal study [Poster presentation]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1539 Vancouver: Pastorino GMG, et al. Safety and tolerability of second-generation antipsychotics in a pediatric cohort: a real life longitudinal study [poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Available from: https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1539 Yazar adları ve başlık biçimi kongre sisteminden otomatik oluşturulmuştur; kullanmadan önce orijinal posterle karşılaştırın. ## Aynı konudan - [Açığı kapatmak: erişkin DEHB ilacı başlanmadan önce EKG sevk uyumunun iyileştirilmesi, kapalı döngü klinik denetim](https://alisanburak.com/en/wcp-2026-posterler/ev0088) - [Anksiyete bozukluğu olan hastalarda psikobiyotik müdahalesi: ısıl işlem görmüş Lactobacillus paracasei PS23'ün etkilerini inceleyen çift kör randomize kontrollü çalışma](https://alisanburak.com/en/wcp-2026-posterler/ev0126) - [Otizm spektrum bozukluğunda bumetanidin tedavi edici potansiyeli: güncel kanıtlar ve gelecek yönelimleri](https://alisanburak.com/en/wcp-2026-posterler/ev0157) - [Verbaskozid ile otizm spektrum bozukluğu tedavisinin mekanizmaları: ağ farmakolojisi, moleküler yerleştirme ve moleküler dinamik temelli inceleme](https://alisanburak.com/en/wcp-2026-posterler/ev0172) - [Otizm spektrum bozukluğunun çekirdek belirtilerinin tedavisinde kannabidiol: sistematik derleme](https://alisanburak.com/en/wcp-2026-posterler/ev0186) [Tüm WCP 2026 özetleri](https://alisanburak.com/en/wcp-2026-posterler) --- Kaynak / Source: https://alisanburak.com/en/wcp-2026-posterler/so003 İletişim / Contact: Bağdat Caddesi, Veli Güneysu Apt. No:453 K:4 D:9, Suadiye / Kadıköy, İstanbul · +90 532 642 95 25 · info@alisanburak.com · https://alisanburak.com/bagdat-caddesi-psikoterapi-iletisim