# Neurodevelopmental influences on cortical folding in psychotic disorders - URL: https://alisanburak.com/en/wcp-2026-posterler/k811 - Language: en - Last updated: not specified - Page title: Neurodevelopmental influences on cortical folding in psychotic disorders | WCP 2026 Summary > Changes in cortical folding may be interpreted as a biologically grounded imaging marker of early neurodevelopmental vulnerability rather than a consequence of… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/k811) This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it. Symposium PresentationNeuroscience and ImagingReview / Opinion # Neurodevelopmental influences on cortical folding in psychotic disorders Neurodevelopmental influences on cortical folding in psychotic disorders Presenter: Stener Nerland Country: Norway Session: 2410 - PERINATAL PROGRAMMING OF PSYCHOSIS: PLACENTAL, IMMUNE, METABOLIC, AND NEURODEVELOPMENTAL PATHWAYS Date: Thu, 24.09.2026, 08:45 - 09:00 Room: Hall A6 Changes in cortical folding may be interpreted as a biologically grounded imaging marker of early neurodevelopmental vulnerability rather than a consequence of chronic illness. The talk takes as its starting point the limited availability of robust in vivo markers of early neurodevelopmental disruption, despite psychotic disorders being considered within a developmental framework through approaches such as the Developmental Origins of Health and Disease (DOHaD). Because cortical folding (gyrification) develops largely during the fetal and early postnatal periods under the joint influence of genetic and environmental factors, it offers a window into otherwise inaccessible developmental processes in humans, and converging imaging evidence points to altered cortical folding across the psychosis spectrum. A recent large-scale study presented by the speaker demonstrated widespread reductions in local gyrification in adolescents with early-onset psychosis, particularly early-onset schizophrenia; longitudinal analyses in adults with schizophrenia spectrum disorders, meanwhile, indicated stable hypogyria rather than a progressive decline. These findings support the interpretation that alterations in folding are markers of early developmental vulnerability rather than later consequences of chronic illness. Bringing together evidence from early-onset, first-episode, and chronic stages of illness, the presentation discusses how these changes relate to prenatal and perinatal influences, genetic vulnerability, and atypical cortical maturation. It also presents emerging evidence on the prognostic value of cortical folding and its associations with antipsychotic response and clinical course, positioning this measure as a biologically grounded imaging marker for investigating developmental risk and disentangling illness heterogeneity. How to cite this study APA 7: Nerland, S., et al. (2026, September 24). Neurodevelopmental influences on cortical folding in psychotic disorders [Symposium presentation]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. Vancouver: Nerland S, et al. Neurodevelopmental influences on cortical folding in psychotic disorders [symposium presentation]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Author names and title formatting were generated automatically from the congress system; please check them against the original poster before use. ## On the same topic - [5-HTTLPR ve MAOA genotiplerinin Iowa kumar görevinde risk altında karar verme üzerindeki farklı duyarlılık etkileri](https://alisanburak.com/en/wcp-2026-posterler/ev0042) - [Duygusal düzensizliği olan erişkin DEHB hastalarında merkezi noradrenalin taşıyıcısı erişilebilirliğinin [11C]MRB PET/MRI ile in vivo görüntülenmesi ve nicelenmesi](https://alisanburak.com/en/wcp-2026-posterler/ev0065) - [Erişkin DEHB'de sapmış beyin kritikliği: uzun erimli zamansal korelasyonlar ve görüntüleme transkriptomiğinden çıkarımlar](https://alisanburak.com/en/wcp-2026-posterler/ev0067) - [Anksiyete biyobelirteci olarak fibroblast büyüme faktörü 2: tehdide yönelik dikkat yanlılığıyla ilişkileri](https://alisanburak.com/en/wcp-2026-posterler/ev0120) - [Trajedi paradoksu: hüzünlü müzikle olumlu duygudurum düzenlenmesinin psikolojik ve nörobiyolojik mekanizmaları](https://alisanburak.com/en/wcp-2026-posterler/ev0134) [All WCP 2026 summaries](https://alisanburak.com/en/wcp-2026-posterler) --- Kaynak / Source: https://alisanburak.com/en/wcp-2026-posterler/k811 İletişim / Contact: Bağdat Caddesi, Veli Güneysu Apt. No:453 K:4 D:9, Suadiye / Kadıköy, İstanbul · +90 532 642 95 25 · info@alisanburak.com · https://alisanburak.com/bagdat-caddesi-psikoterapi-iletisim