# Cytomegalovirus and herpes simplex virus 1 exposure associated with lower IQ in adolescents with early-onset psychosis - URL: https://alisanburak.com/en/wcp-2026-posterler/k735 - Language: en - Last updated: not specified - Page title: Cytomegalovirus and herpes simplex virus 1 exposure associated with lower IQ in adolescents with early-onset psychosis | WCP 2026 Summary > CMV and HSV-1 seropositivity are associated with substantially lower IQ in adolescents with early-onset psychosis, whereas no such association is observed in h… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/k735) This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it. Nordic Perspectives SessionPsychosis and SchizophreniaCase-control study # Cytomegalovirus and herpes simplex virus 1 exposure associated with lower IQ in adolescents with early-onset psychosis Cytomegalovirus and herpes simplex virus 1 exposures associated with lower iq in adolescents with early-onset psychosis Presenter: Tereza Calkova Country: Sweden Session: 4130 - NEUROBIOLOGICAL, TRANSDIAGNOSTIC, AND ENVIRONMENTAL PERSPECTIVES ON ADOLESCENT PSYCHOTIC DISORDERS Date: Fri, 25.09.2026, 18:15 - 18:30 Room: Hall A7 CMV and HSV-1 seropositivity are associated with substantially lower IQ in adolescents with early-onset psychosis, whereas no such association is observed in healthy controls. The study aims to investigate whether exposure to cytomegalovirus (CMV) and herpes simplex virus type 1 (HSV-1) is associated with intellectual functioning in adolescents with early-onset psychosis (EOP). A pilot study was first conducted with 17 patients with schizophrenia spectrum disorders, followed by an investigation of 37 adolescents diagnosed with EOP and 72 healthy controls. CMV and HSV-1 IgG seropositivity were assessed using solid-phase immunoassays, and intellectual functioning was assessed using the Wechsler Abbreviated Scale of Intelligence; associations between viral serostatus and IQ were examined separately in patients and controls. In the pilot study, CMV seropositivity was associated with substantially lower full-scale IQ (by approximately 20 IQ points). This finding was replicated in the larger sample: CMV seropositivity was associated with an 11.5-point lower IQ (p = 0.011), while HSV-1 seropositivity was independently associated with a 15.4-point lower IQ (p = 0.001). No significant association was found in healthy controls. The authors state that these findings support the hypothesis that neuroimmune mechanisms may contribute to cognitive variability in psychotic disorders through environmental influences, and that immunological and neurodevelopmental perspectives should be considered together. How to cite this study APA 7: Calkova, T., et al. (2026, September 25). Cytomegalovirus and herpes simplex virus 1 exposures associated with lower iq in adolescents with early-onset psychosis [Oral presentation]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. Vancouver: Calkova T, et al. Cytomegalovirus and herpes simplex virus 1 exposures associated with lower iq in adolescents with early-onset psychosis [oral presentation]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Author names and title formatting were generated automatically from the congress system; please check them against the original poster before use. ## On the same topic - [İlk atak psikoz ve esrar kullanım bozukluğu olan gençlerde yardım arama: Back to Reality video oyun serisinden çıkarımlar](https://alisanburak.com/en/wcp-2026-posterler/ev0002) - [Kimyasal bağımlılığın eşlik ettiği tedaviye dirençli şizofreni hastalarında modern antipsikotiklerin kombine kullanımının klinik sonuçları](https://alisanburak.com/en/wcp-2026-posterler/ev0014) - [Şizofrenide bilişsel gerileme: Sosyal işlevsellik üzerindeki etkisi ve bilişsel iyileştirme olanakları](https://alisanburak.com/en/wcp-2026-posterler/ev0018) - [Ağır kişilerarası şiddet öyküsü olan, şizofrenisi olan ve olmayan bireylerde temel benlik bozukluklarının karşılaştırılması](https://alisanburak.com/en/wcp-2026-posterler/ev0103) - [Yoğun çakra odaklı meditasyonla ilişkili bir ergende akut ve geçici psikotik bozukluk: olgu sunumu](https://alisanburak.com/en/wcp-2026-posterler/ev0231) [All WCP 2026 summaries](https://alisanburak.com/en/wcp-2026-posterler) --- Kaynak / Source: https://alisanburak.com/en/wcp-2026-posterler/k735 İletişim / Contact: Bağdat Caddesi, Veli Güneysu Apt. No:453 K:4 D:9, Suadiye / Kadıköy, İstanbul · +90 532 642 95 25 · info@alisanburak.com · https://alisanburak.com/bagdat-caddesi-psikoterapi-iletisim