# Longitudinal epigenomic remodeling and accelerated biological aging in major depressive disorder: preliminary findings from the OPADE project - URL: https://alisanburak.com/en/wcp-2026-posterler/k5196 - Language: en - Last updated: not specified - Page title: Longitudinal epigenomic remodeling and accelerated biological aging in major depressive disorder: preliminary findings from the OPADE project | WCP 2026 Summary > Epigenetic age was found to be significantly higher than chronological age in major depressive disorder, and methylation changes were detected at more than 100… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/k5196) Bu sayfa, 26. Dünya Psikiyatri Kongresi'nde sunulan çalışmanın yapay zekâ desteğiyle hazırlanmış Türkçe özetidir. Çalışmanın sahibi sunan yazarlardır; atıf için orijinal kaynağa başvurun. Serbest Bildiri (Sözlü)Duygudurum ve AnksiyeteBoylamsal kohort # Longitudinal epigenomic remodeling and accelerated biological aging in major depressive disorder: preliminary findings from the OPADE project Longitudinal epigenomic remodeling and accelerated biological aging in major depressive disorder: preliminary results from the opade project Sunan: Roberta Visconti Ülke: Italy Oturum: 3162 - FREE COMMUNICATIONS 06: MOOD DISORDERS: MECHANISMS, RISK FACTORS AND NOVEL TREATMENTS Tarih: Thu, 24.09.2026, 16:55 - 17:05 Salon: Hall K11 Epigenetic age was found to be significantly higher than chronological age in major depressive disorder, and methylation changes were detected at more than 100,000 CpG sites over one year of pharmacological treatment. The aim was to identify disease-associated epigenomic signatures and assess whether accelerated epigenetic aging occurs during treatment, as part of the search for objective molecular biomarkers to support patient stratification and personalized treatment in major depressive disorder (MDD). Genome-wide DNA methylation profiling was performed using the Illumina EPIC array platform on DNA extracted from blood samples collected from patients with MDD followed longitudinally during pharmacological treatment; bioinformatic analyses focused on identifying differentially methylated CpG sites and estimating epigenetic age at baseline and after one year. Preliminary analyses were conducted in approximately 100 patients. Across samples, epigenetic age was significantly higher than chronological age; longitudinal comparisons between baseline and follow-up samples identified more than 100,000 differentially methylated CpG sites, demonstrating widespread epigenomic remodeling. According to the authors, these changes suggest dynamic epigenetic adaptations associated with disease status and/or treatment exposure. Longitudinal changes in DNA methylation support the view that epigenomic markers may serve as indicators of disease biology and treatment response; ongoing multi-omics integration studies within the OPADE consortium aim to identify robust biomarkers that will provide a foundation for personalized approaches in psychiatry. Bu çalışmaya nasıl atıf yapılır? APA 7: Visconti, R., et al. (2026, September 24). Longitudinal epigenomic remodeling and accelerated biological aging in major depressive disorder: preliminary results from the opade project [Oral presentation]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. Vancouver: Visconti R, et al. Longitudinal epigenomic remodeling and accelerated biological aging in major depressive disorder: preliminary results from the opade project [oral presentation]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. 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