# A randomized controlled trial of precuneus-targeted rTMS combined with computerized cognitive training in older adults with mild Alzheimer’s disease - URL: https://alisanburak.com/en/wcp-2026-posterler/k4971 - Language: en - Last updated: not specified - Page title: A randomized controlled trial of precuneus-targeted rTMS combined with computerized cognitive training in older adults with mild Alzheimer’s disease | WCP 2026 Summary > Precuneus-targeted repetitive transcranial magnetic stimulation combined with computerized cognitive training produced significantly greater improvements in co… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/k4971) This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it. Free Paper (Oral Presentation)NeuromodulationRCT # A randomized controlled trial of precuneus-targeted rTMS combined with computerized cognitive training in older adults with mild Alzheimer’s disease A randomized controlled trial of precuneus-targeted rtms combined with cct intervention in elderly patients with mild alzheimer's disease Presenter: Yaming Zhang Country: China Session: 4162 - FREE COMMUNICATIONS 17: PSYCHOPATHOLOGY, PERSONALITY DISORDERS AND NEUROSCIENCE Date: Fri, 25.09.2026, 17:50 - 18:00 Room: Hall K16 Precuneus-targeted repetitive transcranial magnetic stimulation combined with computerized cognitive training produced significantly greater improvements in cognitive function, neuropsychiatric symptoms, and activities of daily living than sham stimulation. The study aimed to provide evidence for nonpharmacological management by evaluating the effects of precuneus-targeted repetitive transcranial magnetic stimulation (rTMS) combined with computerized cognitive training (CCT) on cognitive function, activities of daily living, anxiety, and depression in mild Alzheimer’s disease. The study uses a 1:1 parallel-group randomized controlled trial (RCT) design, with participants randomized to an intervention group receiving precuneus-targeted rTMS plus CCT or a control group receiving sham rTMS plus CCT; data collectors and statisticians are blinded, while participants are aware only of their own procedures. The intervention lasts four weeks (five days per week), with assessments conducted at baseline (T0), at the end of the intervention (T1, four weeks after baseline), and three months later (T2). The primary outcome is global cognitive function measured using the MoCA; secondary outcomes include the ACE-III, Rey Auditory Verbal Learning Test (Rey AVLT), plasma p-tau217, HAMA, HAMD, NPI, ADL, PSQI, and cerebral blood flow measured using fNIRS during a verbal fluency task. No significant between-group differences were found in any outcome measure at baseline (T0). After the intervention (T1) and at the three-month follow-up (T2), the precuneus-targeted rTMS plus CCT group showed significantly greater improvements than the sham rTMS plus CCT group in MoCA, ACE-III, and Rey AVLT scores, reductions in plasma p-tau217, HAMA, HAMD, NPI, ADL, and PSQI scores, and verbal fluency task-related cerebral blood flow (all p < 0.05). Adverse event rates were low and similar in both groups, supporting the safety of the intervention. These findings suggest that the precuneus may be an important therapeutic target for nonpharmacological interventions in mild Alzheimer’s disease; however, studies with larger samples, longer follow-up periods, and investigations of underlying mechanisms are needed to confirm the findings and optimize stimulation parameters. How to cite this study APA 7: Zhang, Y., et al. (2026, September 25). A randomized controlled trial of precuneus-targeted rtms combined with cct intervention in elderly patients with mild alzheimer's disease [Oral presentation]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. Vancouver: Zhang Y, et al. A randomized controlled trial of precuneus-targeted rtms combined with cct intervention in elderly patients with mild alzheimer's disease [oral presentation]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. 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