# Advances in Our Understanding of the Genomic Basis of Depression - URL: https://alisanburak.com/en/wcp-2026-posterler/k2142 - Language: en - Last updated: not specified - Page title: Advances in Our Understanding of the Genomic Basis of Depression | WCP 2026 Summary > The number of genetic variants associated with major depression has increased rapidly, but translating these findings across populations and into clinical prac… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/k2142) This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it. Symposium PresentationMood and AnxietyReview / Opinion # Advances in Our Understanding of the Genomic Basis of Depression Advances in our understanding of the genomic basis of depression Presenter: Andrew McIntosh Country: United Kingdom Session: 4690 - ADVANCEMENTS IN PSYCHIATRIC GENETICS: FROM VARIANT DISCOVERY TO BIOLOGICAL MECHANISM AND CLINICAL ACTIONABILITY Date: Sat, 26.09.2026, 14:45 - 15:00 Room: Hall A6 The number of genetic variants associated with major depression has increased rapidly, but translating these findings across populations and into clinical practice remains a key challenge. The talk explores recent advances in understanding the genomic basis of major depression (MD), a moderately heritable disorder. Larger samples of European ancestry have led to a rapid increase in the number of associated variants. However, in the absence of large-scale trans-ancestry datasets, drawing inferences across populations and translating associations into usable clinical tools and more effective treatments has been difficult. The presentation reports the latest trans-ancestry genetic associations identified by the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC). It then discusses downstream analyses aimed at understanding these associations at the mechanistic level and translating them into opportunities for drug discovery and drug repurposing, alongside studies of within-ancestry and cross-ancestry genetic prediction. The talk concludes with new initiatives within and beyond the PGC to improve the representativeness of research resources and extend insights from genetics to other areas of mental health research. How to cite this study APA 7: McIntosh, A., et al. (2026, September 26). Advances in our understanding of the genomic basis of depression [Symposium presentation]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. Vancouver: McIntosh A, et al. Advances in our understanding of the genomic basis of depression [symposium presentation]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Author names and title formatting were generated automatically from the congress system; please check them against the original poster before use. ## On the same topic - [Dikkat eksikliği hiperaktivite bozukluğu olan beliren yetişkinlerde biriktiricilik belirtileri ve davranışları](https://alisanburak.com/en/wcp-2026-posterler/ev0068) - [Tanı konmamış erişkin dikkat eksikliği/hiperaktivite bozukluğunun anksiyete ve depresif bozukluklar için sürdürücü etken olması: bir literatür derlemesi](https://alisanburak.com/en/wcp-2026-posterler/ev0069) - [DEHB, mükemmeliyetçilik ve öz şefkat: olumsuz duygulanıma giden yollar](https://alisanburak.com/en/wcp-2026-posterler/ev0083) - [Anksiyete ile ilişkili bozukluklarda kendi kendine yönlendirilen sanal gerçeklik terapisinin etkililiği: sistematik derleme ve meta-analiz](https://alisanburak.com/en/wcp-2026-posterler/ev0109) - [Birinci basamakta orta şiddette yaygın anksiyete bozukluğunda bilişsel davranışçı terapinin SSGİ ile karşılaştırılması: kontrollü klinik çalışma](https://alisanburak.com/en/wcp-2026-posterler/ev0110) [All WCP 2026 summaries](https://alisanburak.com/en/wcp-2026-posterler) --- Kaynak / Source: https://alisanburak.com/en/wcp-2026-posterler/k2142 İletişim / Contact: Bağdat Caddesi, Veli Güneysu Apt. No:453 K:4 D:9, Suadiye / Kadıköy, İstanbul · +90 532 642 95 25 · info@alisanburak.com · https://alisanburak.com/bagdat-caddesi-psikoterapi-iletisim