# Using Scandinavian pedigrees to disentangle mechanisms of shared familial risk in psychiatric and cardiometabolic disorders - URL: https://alisanburak.com/en/wcp-2026-posterler/k2113 - Language: en - Last updated: not specified - Page title: Using Scandinavian pedigrees to disentangle mechanisms of shared familial risk in psychiatric and cardiometabolic disorders | WCP 2026 Summary > Nationwide Scandinavian pedigrees enable robust cross-country investigation of the co-occurrence of mental and cardiometabolic disorders, while also demonstrat… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/k2113) Bu sayfa, 26. Dünya Psikiyatri Kongresi'nde sunulan çalışmanın yapay zekâ desteğiyle hazırlanmış Türkçe özetidir. Çalışmanın sahibi sunan yazarlardır; atıf için orijinal kaynağa başvurun. Nordik Perspektifler OturumuHalk Sağlığı ve EpidemiyolojiKayıt temelli soyağacı çalışması # Using Scandinavian pedigrees to disentangle mechanisms of shared familial risk in psychiatric and cardiometabolic disorders Using scandinavian genealogies to disentangle mechanisms of shared familial risk of psychiatric and cardiometabolic disorders Sunan: Øyvind Næss Ülke: Norway Oturum: 4340 - DECIPHERING THE HEART-MIND CONNECTION: LEVERAGING NORDIC GENEALOGY AND GLOBAL COHORTS TO MAP PSYCHIATRIC AND CARDIOMETABOLIC COMORBIDITY Tarih: Sat, 26.09.2026, 09:15 - 09:15 Salon: Hall A7 Nationwide Scandinavian pedigrees enable robust cross-country investigation of the co-occurrence of mental and cardiometabolic disorders, while also demonstrating that pedigree structure can shape register-based genetic inference. The study aimed to investigate the familial aggregation and shared etiology of mental and cardiometabolic disorders by linking national pedigrees to health registers, and to systematically assess how pedigree structure affects these estimates across Scandinavia. Population-wide pedigrees were reconstructed from parent–child links in Denmark, Sweden, and Norway and linked to national patient registers; pedigree structure was compared in terms of connectivity, generational depth, number of relatives, and distribution of relationship types. Harmonized ICD-8 through ICD-10 definitions covered major depressive disorder, autism spectrum disorder, bipolar disorder, schizophrenia, myocardial infarction, stroke, type 2 diabetes, and composite cardiovascular and cardiometabolic disorders; familial risks, register-based heritability, shared environmental effects, and genetic correlations were estimated, and country-specific estimates were pooled using random-effects meta-analysis. The pedigrees included approximately 6.8 million individuals in Denmark, 12.2 million in Sweden, and 7.8 million in Norway, comprising approximately 48, 114, and 66 million pairs of relatives, respectively, and spanning 6 to 7 generations. Pedigree structure differed across countries in connectivity, generational depth, and the distribution of relationship types; familial aggregation was strongest for neurodevelopmental disorders. Heritability ranged from 25% to 75%; the strongest genetic correlations were between major depressive disorder and stroke (0.21) and between major depressive disorder and type 2 diabetes (0.18). Cross-country differences were small to moderate and remained similar after relationship types were harmonized. Bu çalışmaya nasıl atıf yapılır? APA 7: Næss, Ø., et al. (2026, September 26). Using scandinavian genealogies to disentangle mechanisms of shared familial risk of psychiatric and cardiometabolic disorders [Oral presentation]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. Vancouver: Næss Ø, et al. Using scandinavian genealogies to disentangle mechanisms of shared familial risk of psychiatric and cardiometabolic disorders [oral presentation]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. 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