# Neurobiology and Animal Models - URL: https://alisanburak.com/en/wcp-2026-posterler/k1531 - Language: en - Last updated: not specified - Page title: Neurobiology and Animal Models | WCP 2026 Summary > Animal models are an indispensable, but not sufficient, component of a bidirectional cycle of discovery that moves from the clinic to the laboratory and back a… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/k1531) This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it. Symposium PresentationNeuroscience and ImagingReview / Opinion # Neurobiology and Animal Models Neurobiology and animal models Presenter: Sabrina Zequeira Country: United States of America Session: 3091 - BREAKING GROUND: INNOVATIONS IN MENTAL HEALTH DRIVEN BY THE NEW GENERATION OF FEMALE INVESTIGATORS Date: Thu, 24.09.2026, 16:15 - 16:30 Room: Hall A3 Animal models are an indispensable, but not sufficient, component of a bidirectional cycle of discovery that moves from the clinic to the laboratory and back again. The talk examines the role of animal models in elucidating the mechanisms and potential treatment targets of psychiatric disorders that impair multiple domains of functioning and lead to losses in independence and quality of life. It argues that the contribution of animal models is often described as a one-way path from bench to bedside, whereas discovery proceeds in a cycle: clinical observation defines the phenomenon, preclinical research identifies the underlying mechanisms, and these mechanisms return to the clinic as treatment targets. Foundational discoveries in neuroscience are presented as examples of this cycle: clinical observation first delineated the systems supporting basic brain functions, animal experiments revealed how these systems work, and this knowledge shaped the tools used to assess patients today. Contemporary preclinical research is described as sustaining this exchange through cross-species behavioral platforms that measure similar constructs in humans and animals using closely aligned paradigms, helping to narrow the longstanding translational gap. Drawing on rodent models, the talk outlines the distinctive contributions of preclinical research: the ability to manipulate neural circuits to establish causality, access to mechanisms at the cellular and network levels, identification of dysfunction before symptoms emerge, and evaluation of candidate interventions using outcomes comparable to those used in clinical settings. Limitations, such as inadequate representation of sex as a biological variable, are also discussed. In conjunction with the symposium’s digital and public health strands, the talk concludes that complex psychiatric conditions require an integrated strategy in which animal models are indispensable but not sufficient on their own. How to cite this study APA 7: Zequeira, S., et al. (2026, September 24). Neurobiology and animal models [Symposium presentation]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. Vancouver: Zequeira S, et al. Neurobiology and animal models [symposium presentation]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Author names and title formatting were generated automatically from the congress system; please check them against the original poster before use. ## On the same topic - [5-HTTLPR ve MAOA genotiplerinin Iowa kumar görevinde risk altında karar verme üzerindeki farklı duyarlılık etkileri](https://alisanburak.com/en/wcp-2026-posterler/ev0042) - [Duygusal düzensizliği olan erişkin DEHB hastalarında merkezi noradrenalin taşıyıcısı erişilebilirliğinin [11C]MRB PET/MRI ile in vivo görüntülenmesi ve nicelenmesi](https://alisanburak.com/en/wcp-2026-posterler/ev0065) - [Erişkin DEHB'de sapmış beyin kritikliği: uzun erimli zamansal korelasyonlar ve görüntüleme transkriptomiğinden çıkarımlar](https://alisanburak.com/en/wcp-2026-posterler/ev0067) - [Anksiyete biyobelirteci olarak fibroblast büyüme faktörü 2: tehdide yönelik dikkat yanlılığıyla ilişkileri](https://alisanburak.com/en/wcp-2026-posterler/ev0120) - [Trajedi paradoksu: hüzünlü müzikle olumlu duygudurum düzenlenmesinin psikolojik ve nörobiyolojik mekanizmaları](https://alisanburak.com/en/wcp-2026-posterler/ev0134) [All WCP 2026 summaries](https://alisanburak.com/en/wcp-2026-posterler) --- Kaynak / Source: https://alisanburak.com/en/wcp-2026-posterler/k1531 İletişim / Contact: Bağdat Caddesi, Veli Güneysu Apt. No:453 K:4 D:9, Suadiye / Kadıköy, İstanbul · +90 532 642 95 25 · info@alisanburak.com · https://alisanburak.com/bagdat-caddesi-psikoterapi-iletisim