# Introduction to deep brain stimulation for psychiatric indications, with a focus on Gilles de la Tourette syndrome - URL: https://alisanburak.com/en/wcp-2026-posterler/k1035 - Language: en - Last updated: not specified - Page title: Introduction to deep brain stimulation for psychiatric indications, with a focus on Gilles de la Tourette syndrome | WCP 2026 Summary > Deep brain stimulation has become a safe and effective option for carefully selected patients with severe, treatment-resistant Tourette syndrome, but limited e… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/k1035) This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it. Symposium PresentationNeuromodulationReview / Opinion # Introduction to deep brain stimulation for psychiatric indications, with a focus on Gilles de la Tourette syndrome An introduction to dbs in psychiatric indications with a focus on gilles de la tourette syndrome Presenter: Petra Heiden Country: Germany Session: 4180 - ADVANCED SURGICAL THERAPIES FOR REFRACTORY PSYCHIATRIC CONDITIONS - PRACTICAL INTERNATIONAL EXPERIENCE & COLLABORATION Date: Sat, 26.09.2026, 08:00 - 08:15 Room: Hall A2 Deep brain stimulation has become a safe and effective option for carefully selected patients with severe, treatment-resistant Tourette syndrome, but limited evidence makes selecting the optimal target difficult. The talk addresses deep brain stimulation (DBS), which emerged at the end of the 20th century as a promising option for treatment-resistant psychiatric disorders, with its first psychiatric applications in Gilles de la Tourette syndrome (GTS) and obsessive-compulsive disorder; although previous studies have demonstrated symptom improvement, most are limited by small sample sizes and methodological heterogeneity. Although symptoms improve during adolescence or early adulthood in most individuals with GTS, a subgroup continues to experience disabling motor and vocal tics despite optimally delivered behavioral and pharmacological treatments. In the first report by Vandewalle and colleagues in 1999, the centromedian–substantia periventricularis–ventro-oralis internus (CM-Spv-Voi) region of the thalamus was targeted; since then, DBS has become a safe and effective treatment option for carefully selected patients with severe, treatment-resistant GTS. Growing knowledge of GTS pathophysiology has highlighted dysfunction in cortico-striato-thalamo-cortical (CSTC) circuits, prompting investigation of numerous targets, including the thalamus, globus pallidus internus, globus pallidus externus, anterior limb of the internal capsule and nucleus accumbens, and subthalamic nucleus. Meta-analytic evidence indicates significant tic reduction following chronic DBS, with pallidal stimulation yielding particularly favorable outcomes; however, selecting the optimal target remains difficult because this evidence rests on a small number of randomized, double-blind, controlled trials with limited sample sizes. More recent structural and functional connectivity analyses suggest that individualized target selection based on symptom profiles may improve outcomes; advances such as connectome-guided targeting and adaptive DBS are also suggested to have the potential to further improve clinical outcomes in the future. How to cite this study APA 7: Heiden, P., et al. (2026, September 26). An introduction to dbs in psychiatric indications with a focus on gilles de la tourette syndrome [Symposium presentation]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. Vancouver: Heiden P, et al. An introduction to dbs in psychiatric indications with a focus on gilles de la tourette syndrome [symposium presentation]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Author names and title formatting were generated automatically from the congress system; please check them against the original poster before use. ## On the same topic - [Kumar oynama bozukluğunda teta patlama uyarımının klinik etkinliği ve plasebo etkileri: başlangıçtaki anksiyete ve depresyonun rolü](https://alisanburak.com/en/wcp-2026-posterler/ev0055) - [Transkraniyal darbe uyarımı (TPS) Alzheimer hastalığı olan hastalarda uygun bir ek tedavi mi?](https://alisanburak.com/en/wcp-2026-posterler/ev0407) - [Demansta tedaviye dirençli ajitasyonda elektrokonvulsif tedavi: anlatısal derleme](https://alisanburak.com/en/wcp-2026-posterler/ev0414) - [Elektrokonvulsif tedavi sonrası bilişsel değişimin nöroimmün ve psikolojik mekanizmaları: boylamsal MITO-ECT çalışmasının ön sonuçları](https://alisanburak.com/en/wcp-2026-posterler/ev0825) - [Yetişkin tedaviye dirençli depresyon hastalarında DEHB belirtilerini iyileştiren güçlendirilmiş tDCS'nin klinik ve görüntüleme mekanizmaları](https://alisanburak.com/en/wcp-2026-posterler/ev0851) [All WCP 2026 summaries](https://alisanburak.com/en/wcp-2026-posterler) --- Kaynak / Source: https://alisanburak.com/en/wcp-2026-posterler/k1035 İletişim / Contact: Bağdat Caddesi, Veli Güneysu Apt. No:453 K:4 D:9, Suadiye / Kadıköy, İstanbul · +90 532 642 95 25 · info@alisanburak.com · https://alisanburak.com/bagdat-caddesi-psikoterapi-iletisim