# GLP-1 receptor agonists and reward modulation in psychiatry: implications for addictive behaviors and hedonic function - URL: https://alisanburak.com/en/wcp-2026-posterler/ev1109 - Language: en - Last updated: not specified - Page title: GLP-1 receptor agonists and reward modulation in psychiatry: implications for addictive behaviors and hedonic function | WCP 2026 Summary > GLP-1 receptor agonists may alter reward processing beyond appetite regulation; this promising effect in addiction must be balanced against careful assessment… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/ev1109) This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it. EV1109 E-PosterAddictionNarrative review # GLP-1 receptor agonists and reward modulation in psychiatry: implications for addictive behaviors and hedonic function GLP-1 RECEPTOR AGONISTS AND REWARD MODULATION IN PSYCHIATRY: IMPLICATIONS FOR ADDICTIVE BEHAVIOURS AND HEDONIC FUNCTION Presenter: Andreia Castanheira da Silva Country: Portugal Institution: Hospital Garcia de Orta GLP-1 receptor agonists may alter reward processing beyond appetite regulation; this promising effect in addiction must be balanced against careful assessment of hedonic and affective outcomes. The study aimed to examine whether GLP-1-mediated reward modulation offers a transdiagnostic approach to reward-related psychopathology, while also exploring its potential effects on hedonic and affective functioning. The method was a narrative review integrating evidence from preclinical, neuroimaging, observational, and clinical studies; no quantitative data synthesis or pooling of samples was performed. The poster presents a framework extending from semaglutide, exenatide, and liraglutide to central GLP-1 signaling (the nucleus tractus solitarius and widely distributed receptors), and from there to reward circuits (the ventral tegmental area, nucleus accumbens, and ventral striatum). Preclinical evidence indicated that GLP-1 signaling activates reward-related regions and reduces alcohol-related reward in animal models. Human data indicated that exenatide reduced alcohol cue reactivity, whereas drinking outcomes were mixed in the overall study population. A small phase 2 trial reported that semaglutide reduced alcohol self-administration, craving, and the number of drinks per drinking day. The anticipated effects were described as reductions in cue reactivity and craving, along with changes in motivated behavior; outcomes requiring monitoring were listed as hedonic tone, motivation, affective experience, and psychiatric safety. The clinical interpretation is that GLP-1 receptor agonists may reduce incentive salience, but their effects on pleasure, motivation, and affect require prospective assessment; research priorities include identifying patients likely to respond, measuring wanting and liking separately, and demonstrating long-term efficacy. [View the original poster](https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1987) How to cite this study APA 7: da Silva, A. C., et al. (2026, September 23-26). Glp-1 receptor agonists and reward modulation in psychiatry: implications for addictive behaviours and hedonic function [E-poster]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1987 Vancouver: da Silva AC, et al. Glp-1 receptor agonists and reward modulation in psychiatry: implications for addictive behaviours and hedonic function [e-poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Available from: https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1987 Author names and title formatting were generated automatically from the congress system; please check them against the original poster before use. ## On the same topic - [Kannabis kaynaklı psikotik bozuklukta yatışlar ve yeniden yatışlar: retrospektif bir kohort çalışması (2018 ile 2024 arası)](https://alisanburak.com/en/wcp-2026-posterler/ev0001) - [Bağımlılıklarda psikoplasti ve bütünleşik yönetim: ASAM ölçütleri kullanılarak ödül yolağının yeniden biçimlendirilmesine yönelik nörobiyolojik bir algoritma](https://alisanburak.com/en/wcp-2026-posterler/ev0003) - [Slovenya cezaevi hizmetinde depo buprenorfin uygulamasının başlatılması](https://alisanburak.com/en/wcp-2026-posterler/ev0004) - [Bağımlılıklarda metilfenidat: DEHB olan ve olmayan erişkinlerde madde kullanımı ve bağımlılık yapan davranışlara ilişkin gelişen kanıtlar](https://alisanburak.com/en/wcp-2026-posterler/ev0005) - [Malezya'da naltreksonun genişleyen klinik kullanım alanları: madde kullanımı ve madde dışı psikiyatrik bozukluklar açısından çıkarımlar](https://alisanburak.com/en/wcp-2026-posterler/ev0006) [All WCP 2026 summaries](https://alisanburak.com/en/wcp-2026-posterler) --- Kaynak / Source: https://alisanburak.com/en/wcp-2026-posterler/ev1109 İletişim / Contact: Bağdat Caddesi, Veli Güneysu Apt. No:453 K:4 D:9, Suadiye / Kadıköy, İstanbul · +90 532 642 95 25 · info@alisanburak.com · https://alisanburak.com/bagdat-caddesi-psikoterapi-iletisim