# Associations between adverse childhood experiences, personality traits, psychiatric symptoms, and brain connectivity in a transdiagnostic clinical sample

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- Page title: Associations between adverse childhood experiences, personality traits, psychiatric symptoms, and brain connectivity in a transdiagnostic clinical sample | WCP 2026 Summary

> Adverse childhood experiences, borderline personality traits, and psychiatric symptoms are interrelated but exhibit distinct clinical and neural patterns; adve…

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Bu sayfa, 26. Dünya Psikiyatri Kongresi'nde sunulan çalışmanın yapay zekâ desteğiyle hazırlanmış Türkçe özetidir. Çalışmanın sahibi sunan yazarlardır; atıf için orijinal kaynağa başvurun.

EV1044

E-PosterNörobilim ve GörüntülemeKesitsel çalışma

# Associations between adverse childhood experiences, personality traits, psychiatric symptoms, and brain connectivity in a transdiagnostic clinical sample

TRAUMA, PERSONALITY TRAITS, AND PSYCHIATRIC SYMPTOMS: RELATIONSHIPS WITH BRAIN CONNECTIVITY IN A TRANSDIAGNOSTIC CLINICAL SAMPLE

Sunan: Eyal Bergmann

Ülke: Israel

Kurum: Rambam Health Care Campus, Department of Psychiatry

Adverse childhood experiences, borderline personality traits, and psychiatric symptoms are interrelated but exhibit distinct clinical and neural patterns; adverse experiences are selectively associated with default mode network connectivity.

The study aimed to identify the shared and distinct clinical and functional connectivity correlates of adverse childhood experiences, personality traits, and psychiatric symptoms. As part of the Transdiagnostic Connectome Project, 163 participants (99 with and 64 without a psychiatric diagnosis) were assessed. Adverse childhood experiences were measured using the Childhood Trauma Questionnaire (CTQ), personality traits using a 24-item borderline personality disorder (BPD) score derived from the NEO-FFI, and psychiatric symptoms using the first principal component of CGI, MADRS, and PANSS scores (PC1, explaining 66.1% of the variance). Resting-state functional connectivity was estimated using the Schaefer-400 parcellation and summarized at the level of the seven Yeo cortical networks. Analyses used correlations, logistic regression, and linear models adjusted for age, sex, site, and head motion. The three dimensions were interrelated: CTQ and BPD score, r = 0.35 (p < 0.001); CTQ and PC1, r = 0.43 (p < 0.001); and BPD score and PC1, r = 0.50 (p < 0.001). For distinguishing participants with and without a psychiatric diagnosis, the area under the curve (AUC) was 0.59 for the age-and-sex model, increasing to 0.65 with the addition of CTQ, 0.76 with the addition of the BPD score, and 0.86 with the addition of symptoms. When moving from separate models to a joint model, the proportion of significant associations with psychosocial variables decreased from 43% to 10% for CTQ, from 73% to 53% for the BPD score, and from 60% to 20% for symptoms; borderline personality traits showed the broadest pattern of unique associations. Only CTQ was significantly associated with within-network connectivity in the default mode network (a negative effect with a magnitude of β = 0.01, p = 0.002), and an interaction between CTQ and the BPD score was identified (β = 0.01; p = 0.041). The findings indicate that these three dimensions should be modeled jointly when examining the neural correlates of psychopathology.

[Orijinal postere git](https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1279)

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APA 7: Bergmann, E., et al. (2026, September 23-26). Trauma, personality traits, and psychiatric symptoms: relationships with brain connectivity in a transdiagnostic clinical sample [E-poster]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1279

Vancouver: Bergmann E, et al. Trauma, personality traits, and psychiatric symptoms: relationships with brain connectivity in a transdiagnostic clinical sample [e-poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Available from: https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1279

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