# Genetic susceptibility, modifiable lifestyle factors, and perinatal depression: A population-based cohort study in Sweden - URL: https://alisanburak.com/en/wcp-2026-posterler/ev1040 - Language: en - Last updated: not specified - Page title: Genetic susceptibility, modifiable lifestyle factors, and perinatal depression: A population-based cohort study in Sweden | WCP 2026 Summary > Nicotine use before pregnancy and in early pregnancy and high genetic susceptibility to major depressive disorder independently increase the risk of perinatal… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/ev1040) This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it. EV1040 E-PosterPerinatal and Women's HealthCohort # Genetic susceptibility, modifiable lifestyle factors, and perinatal depression: A population-based cohort study in Sweden GENETIC PREDISPOSITION, MODIFIABLE LIFESTYLE FACTORS, AND PERINATAL DEPRESSION: A POPULATION-BASED COHORT STUDY IN SWEDEN Presenter: Qiwei Wang Country: Sweden Nicotine use before pregnancy and in early pregnancy and high genetic susceptibility to major depressive disorder independently increase the risk of perinatal depression and show an additive interaction when both are present. The study aimed to examine whether the association between modifiable lifestyle factors and the risk of perinatal depression (PND) differs according to genetic susceptibility to psychiatric disorders. This was a registry-linked cohort study based on the LifeGene cohort in Sweden between 2001 and 2022; follow-up extended through 1 year postpartum, and the sample comprised 7,315 pregnancies in 4,308 women, with 317 cases of perinatal depression (4.3%) identified. Exposures were body mass index in early pregnancy, cigarette or snus use before pregnancy or in early pregnancy, and psychiatric polygenic risk scores (PRS); the outcome was defined as a first clinical diagnosis of depression or a filled antidepressant prescription during pregnancy or within 1 year postpartum. Risk ratios (RRs) were calculated using cluster-robust standard errors, and additive interaction was assessed using the attributable proportion (AP). Adjusted RRs were 1.29 (95% confidence interval 1.00 to 1.67) for overweight or obesity in early pregnancy, 1.48 (1.06 to 2.07) for nicotine use before pregnancy or in early pregnancy, and 1.65 (1.31 to 2.08) for high genetic susceptibility to major depressive disorder; the reference groups were normal body mass index, no nicotine use, and low PRS, respectively. The frequency of perinatal depression was 3.26% among those with low PRS and no nicotine use, 2.63% among those with low PRS and nicotine use, 5.12% among those with high PRS and no nicotine use, and 8.87% among those with high PRS and nicotine use. Joint exposure showed a positive additive interaction, with an RR of 2.54 (1.69 to 3.81) and an AP of 0.45 (0.13 to 0.77). Risk ranged from 2.03% to 4.41% among those without a psychiatric history, rising to between 16.67% and 28.75% among those with a psychiatric history; the group with all risk factors had an RR of 14.37 (9.12 to 22.62) compared with the group with none. According to the authors, modifiable lifestyle factors may offer targets for prevention, while genetic susceptibility and psychiatric history may improve risk stratification for perinatal depression. [View the original poster](https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1921) How to cite this study APA 7: Wang, Q., et al. (2026, September 23-26). Genetic predisposition, modifiable lifestyle factors, and perinatal depression: a population-based cohort study in sweden [E-poster]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1921 Vancouver: Wang Q, et al. Genetic predisposition, modifiable lifestyle factors, and perinatal depression: a population-based cohort study in sweden [e-poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Available from: https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1921 Author names and title formatting were generated automatically from the congress system; please check them against the original poster before use. ## On the same topic - [Dikkatsizlik ve hiperaktivitenin ötesinde: kadınlarda DEHB'nin yeterince tedavi edilmeyen bir boyutu olarak duygusal disregülasyon](https://alisanburak.com/en/wcp-2026-posterler/ev0078) - [Gebelikte anne tiroid işlev bozukluğunun bebekte otizm spektrum bozukluğuyla ilişkisi: sistematik derleme ve meta-analiz](https://alisanburak.com/en/wcp-2026-posterler/ev0181) - [Hafif ve orta düzey obstetrik yük ile doğum sonrası kırk beşinci ayda boyutsal ruh sağlığı sonuçları](https://alisanburak.com/en/wcp-2026-posterler/ev0237) - [Portekiz toplumunda kabul görmeyen yas ölçeğinin geliştirilmesi ve geçerliğine ilişkin ön veriler](https://alisanburak.com/en/wcp-2026-posterler/ev0290) - [Gebelikte olumlu anne ruh sağlığı ile çocukta psikopatoloji ve sosyoduygusal gelişim: olası mekanizmalar ve yeni yönelimler](https://alisanburak.com/en/wcp-2026-posterler/ev0419) [All WCP 2026 summaries](https://alisanburak.com/en/wcp-2026-posterler) --- Kaynak / Source: https://alisanburak.com/en/wcp-2026-posterler/ev1040 İletişim / Contact: Bağdat Caddesi, Veli Güneysu Apt. 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