# From obsession to psychosis: progression from obsessive-compulsive disorder to schizophrenia - a narrative review - URL: https://alisanburak.com/en/wcp-2026-posterler/ev0928 - Language: en - Last updated: not specified - Page title: From obsession to psychosis: progression from obsessive-compulsive disorder to schizophrenia - a narrative review | WCP 2026 Summary > Obsessive-compulsive disorder and schizophrenia share a clinical and neurobiological continuum, and obsessive-compulsive symptoms may represent a prodrome of p… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/ev0928) Bu sayfa, 26. Dünya Psikiyatri Kongresi'nde sunulan çalışmanın yapay zekâ desteğiyle hazırlanmış Türkçe özetidir. Çalışmanın sahibi sunan yazarlardır; atıf için orijinal kaynağa başvurun. EV0928 E-PosterPsikoz ve ŞizofreniAnlatısal derleme # From obsession to psychosis: progression from obsessive-compulsive disorder to schizophrenia - a narrative review FROM OBSESSION TO PSYCHOSIS: THE PROGRESSION FROM OBSESSIVE-COMPULSIVE DISORDER TO SCHIZOPHRENIA — A NARRATIVE REVIEW Sunan: Nuno Carvalho Ülke: Portugal Obsessive-compulsive disorder and schizophrenia share a clinical and neurobiological continuum, and obsessive-compulsive symptoms may represent a prodrome of psychosis in a subgroup of patients. This review aims to examine progression from obsessive-compulsive disorder (OCD) to schizophrenia, prioritizing epidemiological evidence and evidence of temporal sequencing. A narrative review was conducted by searching PubMed, PsycINFO, and Google Scholar for cohort studies, meta-analyses, reviews, case-control studies, and genetic and neuroimaging studies published between 1994 and 2025. Background data indicated a schizophrenia prevalence of approximately 0.55%, an OCD prevalence of 2-3%, and a prevalence of comorbid OCD in schizophrenia of 12-23%. Among 35,255 patients with OCD followed for eleven years, cumulative progression to schizophrenia was 6-7.8%; meta-regression indicated that the prevalence of obsessive-compulsive symptoms (OCS) in schizophrenia was 30.3%, compared with 1.1-1.8% in the general population. Risk predictors included male sex, autism spectrum disorder, bipolar disorder, cluster A personality disorder, and a family history of schizophrenia; longitudinal studies spanning 1-34 years suggest that childhood OCD may precede adult psychosis and that OCS may represent the prodromal phase in a subgroup. Shared genetic, neurobiological, and environmental etiological factors, common genetic loci/pathways in glutamatergic and dopaminergic systems, and both overlapping and distinct neuroimaging abnormalities have been reported. Clinically, patients with schizophrenia and co-occurring OCS have an earlier illness onset, more pronounced cognitive impairment, and more severe overall psychopathology; the review emphasizes that SSRIs, which are first-line treatments for OCD, may exacerbate psychotic symptoms during the prodromal phase of schizophrenia, highlighting the risk of misdiagnosis and inappropriate pharmacological treatment. The authors recommend early recognition of OCS in at-risk groups, the development of redefined nosological frameworks and tailored interventions for schizo-obsessive presentations, and prioritization of prospective longitudinal designs and genetic/neuroimaging markers. [Orijinal postere git](https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1299) Bu çalışmaya nasıl atıf yapılır? APA 7: Carvalho, N., et al. (2026, September 23-26). From obsession to psychosis: the progression from obsessive-compulsive disorder to schizophrenia — a narrative review [E-poster]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1299 Vancouver: Carvalho N, et al. From obsession to psychosis: the progression from obsessive-compulsive disorder to schizophrenia — a narrative review [e-poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Available from: https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1299 Yazar adları ve başlık biçimi kongre sisteminden otomatik oluşturulmuştur; kullanmadan önce orijinal posterle karşılaştırın. ## Aynı konudan - [İlk atak psikoz ve esrar kullanım bozukluğu olan gençlerde yardım arama: Back to Reality video oyun serisinden çıkarımlar](https://alisanburak.com/en/wcp-2026-posterler/ev0002) - [Kimyasal bağımlılığın eşlik ettiği tedaviye dirençli şizofreni hastalarında modern antipsikotiklerin kombine kullanımının klinik sonuçları](https://alisanburak.com/en/wcp-2026-posterler/ev0014) - [Şizofrenide bilişsel gerileme: Sosyal işlevsellik üzerindeki etkisi ve bilişsel iyileştirme olanakları](https://alisanburak.com/en/wcp-2026-posterler/ev0018) - [Ağır kişilerarası şiddet öyküsü olan, şizofrenisi olan ve olmayan bireylerde temel benlik bozukluklarının karşılaştırılması](https://alisanburak.com/en/wcp-2026-posterler/ev0103) - [Yoğun çakra odaklı meditasyonla ilişkili bir ergende akut ve geçici psikotik bozukluk: olgu sunumu](https://alisanburak.com/en/wcp-2026-posterler/ev0231) [Tüm WCP 2026 özetleri](https://alisanburak.com/en/wcp-2026-posterler) --- Kaynak / Source: https://alisanburak.com/en/wcp-2026-posterler/ev0928 İletişim / Contact: Bağdat Caddesi, Veli Güneysu Apt. 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