# Self-harm and suicidality during intranasal esketamine treatment for treatment-resistant depression with comorbid borderline personality disorder - URL: https://alisanburak.com/en/wcp-2026-posterler/ev0836 - Language: en - Last updated: not specified - Page title: Self-harm and suicidality during intranasal esketamine treatment for treatment-resistant depression with comorbid borderline personality disorder | WCP 2026 Summary > Over six months of follow-up, intranasal esketamine was associated with sustained reductions in self-harm and suicidality, including in the high-risk subgroup… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/ev0836) Bu sayfa, 26. Dünya Psikiyatri Kongresi'nde sunulan çalışmanın yapay zekâ desteğiyle hazırlanmış Türkçe özetidir. Çalışmanın sahibi sunan yazarlardır; atıf için orijinal kaynağa başvurun. EV0836 E-Posterİntihar ve KrizProspektif kohort # Self-harm and suicidality during intranasal esketamine treatment for treatment-resistant depression with comorbid borderline personality disorder SELF-HARM AND SUICIDALITY DURING INTRANASAL ESKETAMINE IN TREATMENT-RESISTANT DEPRESSION WITH COMORBID BORDERLINE PERSONALITY DISORDER Sunan: Fabiola Raffone Ülke: Italy Kurum: ASL Napoli 1 Centro Over six months of follow-up, intranasal esketamine was associated with sustained reductions in self-harm and suicidality, including in the high-risk subgroup with comorbid borderline personality disorder. The study aimed to examine six-month longitudinal changes during adjunctive intranasal esketamine treatment for treatment-resistant depression (TRD), in which borderline personality disorder (BPD) substantially increases the risk of self-harm and suicide; this high-risk group is generally underrepresented in esketamine studies. In a prospective naturalistic cohort design, 90 outpatients with TRD were followed, of whom 45 had comorbid BPD and 45 had no personality disorder. Assessments were conducted using the DSHI, C-SSRS, and BIS-11 at five time points: baseline, week 2, month 1, month 3, and month 6; Friedman, Wilcoxon, and Spearman tests were used in the analyses. Suicidal ideation and suicidal behavior decreased over time (all p < 0.001), as did the number of types of self-harm and the frequency of self-harm episodes (all p < 0.001); reductions from baseline were evident from month 1 onward. In the BPD subgroup, the mean frequency of self-harm episodes declined from 30.8 at baseline to 2.4 at month 6. Baseline impulsivity was associated with self-harm and, to a lesser extent, with suicidality; these associations weakened during follow-up. No serious adverse events, treatment discontinuations, increases in suicidality, or suicide attempts were observed. The authors note that controlled studies are needed to clarify the durability of these effects and the contributions of concurrent treatments and follow-up. [Orijinal postere git](https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/56) Bu çalışmaya nasıl atıf yapılır? APA 7: Raffone, F., Testa, S., Iaccarino, C., Mazzoni, F., Girone, N., De Ciechi, A., Macellaro, M., Martinotti, G., Dell'Osso, B. M., Olivola, M., & Martiadis, V. (2026, September 23-26). Self-harm and suicidality during intranasal esketamine in treatment-resistant depression with comorbid borderline personality disorder [E-poster]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/56 Vancouver: Raffone F, Testa S, Iaccarino C, Mazzoni F, Girone N, De Ciechi A, et al. Self-harm and suicidality during intranasal esketamine in treatment-resistant depression with comorbid borderline personality disorder [e-poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Available from: https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/56 Yazar adları ve başlık biçimi kongre sisteminden otomatik oluşturulmuştur; kullanmadan önce orijinal posterle karşılaştırın. ## Aynı konudan - [Kıyıda erken ölüm: evsizlik yaşayan kişilerde önlenebilir dış nedenler olarak intihar ve doz aşımı](https://alisanburak.com/en/wcp-2026-posterler/ev0089) - [İntihar davranışı ve kendine zarar verme davranışı olan ergenlerde duygu düzenleme güçlüğü ve uyumsuz kişilik özellikleri: bakım düzeyine göre farklılıklar](https://alisanburak.com/en/wcp-2026-posterler/ev0226) - [Ergenlik ölümcül olabilir mi? 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