# The L-PGDS/15d-PGJ2/CRTH2 axis causes synaptic impairment in depression by regulating astrocyte–neuron crosstalk - URL: https://alisanburak.com/en/wcp-2026-posterler/ev0817 - Language: en - Last updated: not specified - Page title: The L-PGDS/15d-PGJ2/CRTH2 axis causes synaptic impairment in depression by regulating astrocyte–neuron crosstalk | WCP 2026 Summary > Plasma 15d-PGJ2 levels are elevated in major depressive disorder, and the astrocyte-derived L-PGDS/15d-PGJ2/CRTH2 signaling axis in the amygdala mediates depre… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/ev0817) Bu sayfa, 26. Dünya Psikiyatri Kongresi'nde sunulan çalışmanın yapay zekâ desteğiyle hazırlanmış Türkçe özetidir. Çalışmanın sahibi sunan yazarlardır; atıf için orijinal kaynağa başvurun. EV0817 E-PosterNörobilim ve GörüntülemeDeneysel çalışma (klinik örneklem ve hayvan modeli) # The L-PGDS/15d-PGJ2/CRTH2 axis causes synaptic impairment in depression by regulating astrocyte–neuron crosstalk THE L-PGDS/15D-PGJ2/CRTH2 AXIS DRIVES SYNAPTIC IMPAIRMENT IN DEPRESSION BY REGULATING ASTROCYTE-NEURON CROSSTALK Sunan: Siyuan Jiang Ülke: China Kurum: Southeast University, Zhongda Hospital, Department of Psychosomatics and Psychiatry Plasma 15d-PGJ2 levels are elevated in major depressive disorder, and the astrocyte-derived L-PGDS/15d-PGJ2/CRTH2 signaling axis in the amygdala mediates depression-like behaviors and synaptic impairment. The aim is to elucidate the cellular mechanisms of impaired synaptic plasticity in major depressive disorder (MDD) by examining the role of the L-PGDS/15d-PGJ2/CRTH2 axis in astrocyte–neuron crosstalk in the amygdala. The methods included untargeted metabolomic sequencing of plasma from patients with MDD, followed by molecular biological validation of the brain regions and cell types showing 15d-PGJ2 accumulation in the chronic social defeat stress (CSDS) mouse model of depression. Genes upstream and downstream in the pathway were then silenced or overexpressed using genetic tools. Behavioral assessments included the social interaction test (SIT), sucrose preference test (SPT), tail suspension test (TST), and forced swim test (FST). The findings showed a significant increase in prostaglandin J2 in the MDD group (fold change = 1.995; p = 3.89 × 10^-5). Plasma 15d-PGJ2 levels were higher in patients than in controls and positively correlated with HAMD-24 scores; no significant difference in plasma levels was detected between women and men (ns). Administration of 15d-PGJ2 (0.01 mg/kg) into the amygdala induced depression-like behaviors in mice, as measured by the SPT, TST, and FST. In the CSDS model, upregulation of L-PGDS in amygdala astrocytes increased the pathological accumulation of 15d-PGJ2, while administration of AZD1981 and GW9662 (2 mg/kg/day, i.p.) improved behavioral outcomes; CRTH2 mRNA levels were elevated in stress-susceptible animals compared with controls. In conclusion, the study identifies a mechanistic link between disrupted lipid metabolism and neuronal dysfunction, suggesting that this axis may be explored for biomarker development and targeted treatment in MDD. [Orijinal postere git](https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/526) Bu çalışmaya nasıl atıf yapılır? APA 7: Jiang, S. (2026, September 23-26). The l-pgds/15d-pgj2/crth2 axis drives synaptic impairment in depression by regulating astrocyte-neuron crosstalk [E-poster]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/526 Vancouver: Jiang S. The l-pgds/15d-pgj2/crth2 axis drives synaptic impairment in depression by regulating astrocyte-neuron crosstalk [e-poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Available from: https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/526 Yazar adları ve başlık biçimi kongre sisteminden otomatik oluşturulmuştur; kullanmadan önce orijinal posterle karşılaştırın. ## Aynı konudan - [5-HTTLPR ve MAOA genotiplerinin Iowa kumar görevinde risk altında karar verme üzerindeki farklı duyarlılık etkileri](https://alisanburak.com/en/wcp-2026-posterler/ev0042) - [Duygusal düzensizliği olan erişkin DEHB hastalarında merkezi noradrenalin taşıyıcısı erişilebilirliğinin [11C]MRB PET/MRI ile in vivo görüntülenmesi ve nicelenmesi](https://alisanburak.com/en/wcp-2026-posterler/ev0065) - [Erişkin DEHB'de sapmış beyin kritikliği: uzun erimli zamansal korelasyonlar ve görüntüleme transkriptomiğinden çıkarımlar](https://alisanburak.com/en/wcp-2026-posterler/ev0067) - [Anksiyete biyobelirteci olarak fibroblast büyüme faktörü 2: tehdide yönelik dikkat yanlılığıyla ilişkileri](https://alisanburak.com/en/wcp-2026-posterler/ev0120) - [Trajedi paradoksu: hüzünlü müzikle olumlu duygudurum düzenlenmesinin psikolojik ve nörobiyolojik mekanizmaları](https://alisanburak.com/en/wcp-2026-posterler/ev0134) [Tüm WCP 2026 özetleri](https://alisanburak.com/en/wcp-2026-posterler) --- Kaynak / Source: https://alisanburak.com/en/wcp-2026-posterler/ev0817 İletişim / Contact: Bağdat Caddesi, Veli Güneysu Apt. 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