# Effects of medical interventions on neonatal DNA methylation in threatened preterm labor - URL: https://alisanburak.com/en/wcp-2026-posterler/ev0259 - Language: en - Last updated: not specified - Page title: Effects of medical interventions on neonatal DNA methylation in threatened preterm labor | WCP 2026 Summary > Among neonatal intensive care interventions, ventilation was associated with 3 CpG sites and cesarean delivery with 1 CpG site, while no significant associatio… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/ev0259) This page is an AI-assisted Turkish summary of the study presented at the 26th World Congress of Psychiatry. The study belongs to the presenting authors; please refer to the original source when citing it. EV0259 E-PosterNeuroscience and ImagingCohort # Effects of medical interventions on neonatal DNA methylation in threatened preterm labor IMPACT OF MEDICAL INTERVENTIONS ON NEONATAL DNA METHYLATION IN THREATENED PRETERM LABOR Presenter: Adrián Torres-Villasante Country: Spain Institution: Health Research Institute Hospital La Fe (IIS La Fe), Mental Health Research Group Among neonatal intensive care interventions, ventilation was associated with 3 CpG sites and cesarean delivery with 1 CpG site, while no significant association was found with corticosteroid exposure. The study aimed to assess the effects of neonatal medical interventions on DNA methylation in infants exposed to threatened preterm labor (TPL), identify CpG sites associated with ventilation, cesarean delivery, and corticosteroid exposure, and examine the functional pathways affected. DNA methylation was profiled using dried blood spot samples collected at 48 hours of life from 99 neonates exposed to TPL (55 males, 44 females; gestational age 23 to 37 weeks, mean 30.4 ± 3.2 weeks). Associations between ventilation, cesarean delivery, and corticosteroid exposure and CpG methylation were evaluated using rank-based regression models, with false discovery rate (FDR) correction for multiple comparisons, and Gene Ontology enrichment was analyzed using GeneCodis3. Three CpG sites associated with neonatal ventilation were identified; these mapped to the CCDC67 and GSTTP2 genes and implicated oxidative stress pathways. One CpG site associated with cesarean delivery was identified in PGM5P2, a pseudogene linked to carbohydrate metabolism; corticosteroid exposure showed no significant association. Although these effects were small compared with those of gestational age and sex, they indicate that intensive care interventions leave detectable molecular traces. The study concluded that neonatal medical interventions leave measurable signatures on the methylome and, although lifesaving, may create subtle epigenetic vulnerabilities in preterm infants. [View the original poster](https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/2354) How to cite this study APA 7: Torres-Villasante, A., Lizarán, M., Moreno-Giménez, A., Andreu-Martínez, J., Ferrer-Ricart, R., Campos-Berga, L., Pina-Camacho, L., Parellada, M., & García-Blanco, A. (2026, September 23-26). Impact of medical interventions on neonatal dna methylation in threatened preterm labor [E-poster]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/2354 Vancouver: Torres-Villasante A, Lizarán M, Moreno-Giménez A, Andreu-Martínez J, Ferrer-Ricart R, Campos-Berga L, et al. Impact of medical interventions on neonatal dna methylation in threatened preterm labor [e-poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. 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