# Is bipolar disorder a procoagulant state? A lithium study - URL: https://alisanburak.com/en/wcp-2026-posterler/ev0200 - Language: en - Last updated: not specified - Page title: Is bipolar disorder a procoagulant state? A lithium study | WCP 2026 Summary > Patients with bipolar disorder who have never received lithium have higher levels of procoagulant extracellular vesicles than controls, their haemostatic statu… This page was translated automatically from Turkish. [Read the original](https://alisanburak.com/wcp-2026-posterler/ev0200) Bu sayfa, 26. Dünya Psikiyatri Kongresi'nde sunulan çalışmanın yapay zekâ desteğiyle hazırlanmış Türkçe özetidir. Çalışmanın sahibi sunan yazarlardır; atıf için orijinal kaynağa başvurun. EV0200 E-PosterPsikofarmakolojiProspektif kohort (kontrol gruplu izlem) # Is bipolar disorder a procoagulant state? A lithium study IS BIPOLAR DISORDER A PROCOAGULANT STATE? A LITHIUM STUDY Sunan: Katja Ponzer Ülke: Sweden Kurum: Karolinska Institutet, Department of Molecular Medicine and Surgery Patients with bipolar disorder who have never received lithium have higher levels of procoagulant extracellular vesicles than controls, their haemostatic status is heterogeneous, and lithium exhibits a transient fibrinolytic effect during the first year. Objective: Although bipolar disorder (BD) is known to be associated with an increased risk of venous thromboembolism, the role of lithium in this process remains insufficiently characterised. This study therefore aimed to examine coagulation-related measurements and biomarkers in patients with BD, both at baseline and during the first two years of lithium treatment. Methods: Plasma samples were collected at baseline from 52 patients with bipolar disorder and 42 healthy controls, with repeat sampling in patients at weeks 2 and 6 and months 12 and 24. Extracellular vesicles (EVs) were counted using flow cytometry, and overall coagulation potential (OCP) and overall fibrinolytic potential (OFP) were calculated using the overall haemostatic potential (OHP) assay. The EV surface markers examined were Annexin V, CD42b, CD142 (tissue factor), CD45, CD62p (P-selectin), and CD62e (E-selectin). Results: At baseline, patients had significantly higher total EV counts than controls (Annexin V, p=0.005 and p=0.006 for panels A and B, respectively), as well as significantly higher counts of platelet-derived EVs (p=0.005 and p=0.007), leukocyte-derived EVs (p=0.006), tissue factor-bearing EVs (p=0.018 and p=0.021), E-selectin-bearing EVs (p=0.007), and P-selectin-bearing EVs (p=0.006). OCP and OFP were normal in 30% of patients, OCP was elevated in 35%, and OFP was elevated in 35%. In the group with normal baseline values, OFP increased at weeks 2 and 6 and month 12 after lithium initiation, but this effect was not observed at month 24. No effect of lithium on OCP or OFP was detected in the other groups, and the observed differences could not be explained by antipsychotic use or demographic variables. Preliminary findings indicated that initiation of lithium treatment did not significantly affect EV levels over time. Conclusion: Haemostatic status is heterogeneous in patients with bipolar disorder, and lithium may have a transient fibrinolytic effect; this finding may be considered when assessing thromboembolic risk. [Orijinal postere git](https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1695) Bu çalışmaya nasıl atıf yapılır? APA 7: Ponzer, K., Gran, C., Österholm, C., Lundberg, M., Månsson, K. N., Schalling, M., Antovic, J. P., Backlund, L., & Lavebratt, C. (2026, September 23-26). Is bipolar disorder a procoagulant state? a lithium study [E-poster]. 26th WPA World Congress of Psychiatry (WCP 2026), Stockholm, Sweden. https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1695 Vancouver: Ponzer K, Gran C, Österholm C, Lundberg M, Månsson KN, Schalling M, et al. Is bipolar disorder a procoagulant state? a lithium study [e-poster]. 26th WPA World Congress of Psychiatry (WCP 2026); 2026 Sep 23-26; Stockholm, Sweden. Available from: https://cslide.ctimeetingtech.com/wcp26/attendee/eposter/file/1695 Yazar adları ve başlık biçimi kongre sisteminden otomatik oluşturulmuştur; kullanmadan önce orijinal posterle karşılaştırın. ## Aynı konudan - [Açığı kapatmak: erişkin DEHB ilacı başlanmadan önce EKG sevk uyumunun iyileştirilmesi, kapalı döngü klinik denetim](https://alisanburak.com/en/wcp-2026-posterler/ev0088) - [Anksiyete bozukluğu olan hastalarda psikobiyotik müdahalesi: ısıl işlem görmüş Lactobacillus paracasei PS23'ün etkilerini inceleyen çift kör randomize kontrollü çalışma](https://alisanburak.com/en/wcp-2026-posterler/ev0126) - [Otizm spektrum bozukluğunda bumetanidin tedavi edici potansiyeli: güncel kanıtlar ve gelecek yönelimleri](https://alisanburak.com/en/wcp-2026-posterler/ev0157) - [Verbaskozid ile otizm spektrum bozukluğu tedavisinin mekanizmaları: ağ farmakolojisi, moleküler yerleştirme ve moleküler dinamik temelli inceleme](https://alisanburak.com/en/wcp-2026-posterler/ev0172) - [Otizm spektrum bozukluğunun çekirdek belirtilerinin tedavisinde kannabidiol: sistematik derleme](https://alisanburak.com/en/wcp-2026-posterler/ev0186) [Tüm WCP 2026 özetleri](https://alisanburak.com/en/wcp-2026-posterler) --- Kaynak / Source: https://alisanburak.com/en/wcp-2026-posterler/ev0200 İletişim / Contact: Bağdat Caddesi, Veli Güneysu Apt. 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